CareLit Fachartikel

Treatment of elderly patients with advanced ovarian cancer in the context of controlled clinical trials – A joint analysis of 3 AGO-Ovar subprojects

F Hilpert, P Harter, P Wimberger, R Kimmig, J Pfisterer, A du Bois · Geburtshilfe und Frauenheilkunde · 2008 · Heft 09

Dokument
1164703
CareLit-ID
Jahr
2008
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
F Hilpert, P Harter, P Wimberger, R Kimmig, J Pfisterer, A du Bois
Ausgabe
Heft 09 / 2008
Seiten
–
Erschienen: 2008-09-12 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0028-1088619

Zusammenfassung

Aims: Elderly are the fastest-growing segment of patients (pts) with ovarian cancer (OC). Despite optimization of OC treatment, age remains a negative prognostic factor. Methods: In three subprotocols of the AGO-OVAR the impact of age on quality of life (Qol), safety, feasibility and efficacy of platinum-paclitaxel-based treatment (Ovar–3 subprotocols) and participation in clinical trials (OVAR 7 subprotocol Ovar 14) has been investigated. Results: In the Ovar–3 only 103 of 787 pts were ≥ 70 years. The number of cycles was significantly lower and early discontinuation more frequent in elderly, although Qol, non-…

Schlagworte

clinical trials elderly patients ovarian cancer Elderly Treatment Significant Clinical Trials Impact Toxicity Younger Patients Ovarian Cancer Analysis Geburtshilfe und Frauenheilkunde