Enhanced T cell transmigration across murine liver sinusoidal endothelium is mediated by transcytosis and surface presention of chemokines

Transmigration through liver endothelium is a prerequisite for the homeostatic balance of intrahepatic T cells and a key regulator of inflammatory processes within the liver. Extravasation into the liver parenchyma is regulated by the distinct expression patterns of adhesion molecules and chemokines and their receptors on the lymphocyte and endothelial cell surface. In the present study we investigated whether liver sinusoidal endothelial cells (LSEC) inhibit or support the chemokine-driven transmigration and differentially influence the transmigration of pro- or anti-inflammatory CD4+ T cells, indicating a mech…