Temoporfin improves tumoricidal efficacy of photodynamic therapy (PDT) for bile duct cancer
G Wolkersdörfer, K Emanuel, U Denzer, A Püspök, D Neureiter, T Kiesslich, A Lohse, F Berr · Zeitschrift für Gastroenterologie · 2008 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aim: Local ablation of hilar bile duct cancer (BDC) using porfimer and laser irradiation (632nm) of tumour stenoses improves obstructive cholestasis and survival time, although the tumoricidal effect is confined to inner 4mm of the tumour wall (6–9mm) resulting in TTP >6 months. We have studied (EUDRA CT Nr.2005–004866–17), whether temoporfin-based PDT (T-PDT, 652 nM) shows twice as deep tumoricidal tissue penetration and similar adverse events. Methods: Eleven patients (7:4 f/m; age 71 [55–88] yrs) with hilar BDC (Bismuth III and IV) were treated with T-PDT and analysed according to the two-stage Simon optimal…
