CareLit Fachartikel
Hepatoprotectant Ursodeoxycholyllysophosphatidylethanolamide Evokes ERK/MAPK and PI3K/Akt Survival Signalling
W Chamulitrat, J Burhene, T Reheln, A Pathil, W Stremmel · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1165151
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
We had synthesized the bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide (UDCA-LPE) which was designed to target hepatocytes via bile-acid transport systems. By using a fluorescent labelled analog UDCA-NBDPE, we showed that the conjugate was taken up by HepG2 cells and also targeted the liver in vivo. We also showed that UDCA-LPE was cytoprotective in HepG2 cells during starvation and TNF-α-induced apoptosis. Here we demonstrated that PI3K inhibitor LY294002 reversed cytoprotective effects of UDCA-LPE in both experimental models indicating that PI3K/Akt pathway may be involved in cyto…
Schlagworte
liver disease
phospholipids
survival signalling
Apoptosis
Caspase 8
Zeitschrift für Gastroenterologie
