Detection of Novel Biomarkers of Liver Cirrhosis by Proteomic Analysis
C Mölleken, B Sitek, C Henkel, G Poschmann, B Sipos, S Wiese, B Warscheid, M Reiser, S Friedman, I Tornoe, A Schlosser, G Klöppel, W Schmiegel, HE Meyer, U Holmskov, K Stühler · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Bibliografische Angaben
Zusammenfassung
Hepatic cirrhosis is a life-threatening disease arising from different chronic liver disorders. One major cause for hepatic cirrhosis is chronic hepatitis C. Chronic hepatitis C, which is characterized by a highly variable clinical course, with at least ˜20% developing liver cirrhosis within 40 years. Since so far only liver biopsy allows a reliable evaluation of the course of hepatitis C by grading inflammation and staging fibrosis, serum biomarkers for hepatic fibrosis with high sensitivity and specificity are needed. In order to identify new candidate biomarkers for hepatic fibrosis, we microdissected cirrhot…
