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Increased hepatic glucosylceramide levels in GBA2 deficient mice are beneficial during the early phase of liver regeneration

AM Oprisoreanu, E Almajan, SN Weber, F Lammert, T Sauerbruch, Y Yildiz · Zeitschrift für Gastroenterologie · 2009 · Heft 01

Dokument
1165159
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
AM Oprisoreanu, E Almajan, SN Weber, F Lammert, T Sauerbruch, Y Yildiz
Ausgabe
Heft 01 / 2009
Seiten
–
Erschienen: 2009-01-20 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1191839

Zusammenfassung

Introduction: Gba2 knockout mice accumulate the glycolipid glucosylceramide in different tissues, including the liver. Glycolipids are a class of cellular membrane lipids that differ from the regular membrane phospholipids in a remarkable variation in its head group structures. This suggests that glycolipids serve specialized functions in cell signaling, differentiation and recognition processes (van Meer et al. 2003). Different studies have suggested a special role of glycolipids in cell cycle and cell proliferation. Our aim was to investigate the role of glucosylceramide in liver regeneration using the two-thi…

Schlagworte

glucosylceramide liver regeneration Bromodeoxyuridine Cyclin D After Zeitschrift für Gastroenterologie