CareLit Fachartikel
The hepatic acute phase response controls inflammation during sepsis by promoting myeloid suppressor cell functions
LE Sander, S Dutton-Sackett, C Trautwein · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1165168
CareLit-ID
Jahr
2009
Publikation
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Metadaten
DOI
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Zusammenfassung
Sepsis is a major cause of mortality worldwide characterized by a dysregulated inflammatory response to infection. Patients with chronic liver diseases have significantly increased risk of acquiring sepsis and and show a higher sepsis related mortality. The underlying mechanisms are only partially understood. The liver is the major source of acute phase proteins (APPs) which are regarded as important components of the innate immune response. However, due to the large diversity of APPs with pro- and anti-inflammatory functions, their overall role in infections is not well defined. Here we show that a critical reg…
Schlagworte
Acute phase response
myeloid derived suppressor cells
Sepsis
Cytokine
Cytokine Receptor gp130
Acute-Phase Proteins
Adoptive Transfer
Population
Chemokine
Amyloid
Amyloid A
Zeitschrift für Gastroenterologie
