CareLit Fachartikel
Spontaneous Chronic Liver Inflammation in a Transgenic Mouse Model of Autoimmune Hepatitis: Impact and Regulation of Autoreactive CD8+ T Cells
M Zierden, E Kühnen, M Odenthal, HP Dienes · Zeitschrift für Gastroenterologie · 2009 · Heft 01
Dokument
1165169
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Jahr
2009
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Zusammenfassung
Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown cause. Autoreactive T cells are believed to trigger the destruction of hepatocytes but the pathogenesis of AIH remains poorly understood. To investigate liver-specific CD8+ T-cell responses as well as the impact and regulation of autoreactive CD8+ T cells in the pathogenesis of AIH, we have generated transgenic mice that express the influenza virus hemagglutinin (HA) model antigen under the control of albumin regulatory elements exclusively in the liver (Alb-HA mice), affording presentation of the antigen by hepatocytes and by professi…
Schlagworte
Hepatitis
Autoimmune Hepatitis
Adoptive Transfer
Autoimmunity
Apoptosis
Alanine
Zeitschrift für Gastroenterologie
