CareLit Fachartikel

Molecular basis of increased Defensin Beta-1 gene expression in the lung of COPD patients

E Andresen, J Bullwinkel, C Lange, H Heine · Pneumologie · 2009 · Heft 03

Dokument
1165290
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
E Andresen, J Bullwinkel, C Lange, H Heine
Ausgabe
Heft 03 / 2009
Seiten
–
Erschienen: 2009-03-02 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0029-1214059

Zusammenfassung

Defensins are components of the host response against bacterial infections and regulators of inflammation and immunity. The first discovered human Defensin Beta-1 (DEFB1), has been largely considered as a constitutively expressed defensin, but recent observations suggest some sort of DEFB1 gene regulation in a variety of cell types. In patients with chronic obstructive pulmonary disease (COPD), our data demonstrate a significant increase in DEFB1 mRNA expression in bronchial biopsy samples that correlates with disease severity. The molecular mechanisms responsible for the upregulation of DEFB1 gene expression ar…

Schlagworte

Acetylation Bacterial Infections Deoxycytidine Defensins Biopsy Pneumologie