CareLit Fachartikel

TGF-β supervises centrosome amplification and tetraploidy in the mammary gland

MC Fleisch, CA Maxwell, C Kuper, SV Costes, MH Barcellos-Hoff · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09

Dokument
1165382
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
MC Fleisch, CA Maxwell, C Kuper, SV Costes, MH Barcellos-Hoff
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-19 00:00:00
ISSN
0016-5751
DOI
10.1055/s-2006-952539

Zusammenfassung

At its earliest stages, prior to mutational loss of p53, breast cancer is characterized by centrosomal abnormalities (CA) and chromosomal instability (Lingle 2002) and shows signs of constitutive DNA damage response (Bartkova 2005). Genetic instability potentially occurs through impaired responses to damage from exogenous agents, and/or environmental stress within p53 competent cells. High doses of IR, an established carcinogen but also therapeutic of the breast induces CA within tumor cells (Sato 2000). It is unknown if IR or environmental stress is able to induce CA in normal p53 competent cells, and if, wheth…

Schlagworte

Breast Chromosomal Instability Population Cytokine Tumor Geburtshilfe und Frauenheilkunde