CareLit Fachartikel
Zelluläre Immuntherapie beim metastasiertem Mammakarzinom mit reaktivierten T-Gedächtniszellen
F Schütz, K Ehlert, AJ Schneeweiss, P Beckhove, V Schirrmacher, C Sohn · Geburtshilfe und Frauenheilkunde · 2006 · Heft 09
Dokument
1165398
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Tumor-reactive CD4 and CD8 memory T cells (MTC) can be found in bone marrow (BM) of the majority of primary and metastatic breast cancer patients. In xenotransplant mouse models these cells, upon specific re-activation ex vivo, mediated efficient rejection of autologous breast tumors suggesting that the polyclonal natural MTC repertoire possesses therapeutic potential. In order to clinically exploit these anti-tumor capacities we treated 11 advanced metastasized breast cancer patients with autologous, tumor-reactive, reactivated MTC of BM in a phase-1 trial. Activation of T cells was done by MCF-7 lysate pulsed…
Schlagworte
Breast
Blood
Tumor
After
Dendritic Cells
Cytokine
Mammakarzinom
Geburtshilfe und Frauenheilkunde
