In vivo amyloid imaging with the new radiotracer [N-Methyl-11C]2-(4'-(methylamino)phenyl)-benzothiazol (C-11-BTA-1) in Alzheimer's disease
C.A.F. von Arnim, K. Gerhard, S. Thees, S. Deisenhofer, B. Neumaier, I. Uttner, A.C. Ludolph, S.N. Reske, F.M. Mottaghy · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: Over the last years there has been great effort to develop novel in vivo amyloid-imaging radiotracers for use with positron emission tomography (PET) to allow noninvasive in vivo assessments of amyloid plaques. This might lead to a better understanding of amyloid deposition over the course of disease in Alzheimer's disease (AD), and might eventually provide a surrogate marker of potential antiamyloid therapies. In this pilot study we evaluated the thioflavin t derivative C-11-BTA-1 in AD patients by using a whole brain approach implemented in SPM2 in comparison to a healthy control group. Methods: 10 AD pa…
