Over-expression of innate immune receptors during normal brain ageing

Brain ageing results in impairment of cognitive functions and is a major risk factor for several neurodegenerative diseases such as Alzheimer's disease or Parkinson's disease. Previous studies of diseased brains have described neuroinflammatory alterations and upregulation of specific innate immune receptors, notably the toll-like receptors (TLRs) 1–9 and the lipopolysaccharide (LPS) receptor CD14. Here, we investigated whether these innate immune receptors expression is altered also during normal aging of the brain, thus in absence of any cerebral pathology. Using Real-time PCR method, we compared expression of…