Imaging cognitive fatigue in encephalomyelitis disseminata: a fMRI study

Aims: Fatigue is a very common symptom of encephalomyelitis disseminata which has a great impact on qualitiy of life and poductivity. Diagnosis of fatigue is currently made by structured interviews and self assessment scores. The aim of our study is to investigate the organic basis of fatigue and to develop an objective marker of fatigue in encephalomyelitis disseminata using functional magnetic resonance imaging (fMRI). Methods: We investigated 19 patients with confirmed diagnosis of encephalomyelitis disseminata reporting fatigue in a cross-sectional, prospective study. Patients with severe motor disabilities…