Release of glial fibrillary acidic protein and protein S100B are related to the neurovascular status in acute ischaemic stroke

Aims: This study aimed at an analysis of Glial Fibrillary Acidic Protein (GFAP) and Protein S100B in acute ischemic stroke, their association with the neurovascular status and potential value as monitoring parameters. Methods: In 69 consecutive patients, serial venous blood samples were taken on admission, 6, 12, 18, 24, 48, 72, 96, and 120 hours after stroke onset. The neurovascular status was assessed by repetitive extracranial and transcranial duplex sonography. Neurological deficits were quantified by the NIH stroke scale, and functional outcome was assessed with the modified Rankin Scale. Results: Mean GFAP…