CareLit Fachartikel

Bone marrow-derived microglia significantly contribute to the pathology following Streptococcus pneumoniae meningitis in mice

M. Djukic, A. Mildner, H. Schmidt, D. Czesnik, W. Brück, J. Priller, R. Nau, M. Prinz · Aktuelle Neurologie · 2006 · Heft 09

Dokument
1165460
CareLit-ID
Jahr
2006
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Aktuelle Neurologie
Autor:innen
M. Djukic, A. Mildner, H. Schmidt, D. Czesnik, W. Brück, J. Priller, R. Nau, M. Prinz
Ausgabe
Heft 09 / 2006
Seiten
–
Erschienen: 2006-09-27 00:00:00
ISSN
0302-4350
DOI
10.1055/s-2006-953369

Zusammenfassung

Objectives: Previous studies have demonstrated a potential role of brain endogenous microglia and meningeal macrophages in inflammation and neuronal injury in bacterial meningitis. However, the contribution of postnatally invading hematopoietic microglia to this process is still unknown. Methods: To investigate the kinetics of microglial engraftment we used genetically labelled bone marrow-derived cells (BMC) from transgenic mice driving GFP under the beta chicken actin pomotor to deliver fluorescence-labelled microglia to the diseased brain. 8 weeks after transplantation, 104CFU of S. pneumoniae were injected i…

Schlagworte

Meningitis After Blood Actin Transplantation Aktuelle Neurologie