Neuropathological classification of Ammon's horn sclerosis
M. Hildebrandt, E. Pauli, J. Romstöck, H. Stefan, J. Schramm, H. Clusmann, A. Becker, C.E. Elger, J. Zentner, C. Scheiwe, B. Volk, A. Schulze-Bonhage, H. Meencke, T. Lehmann, I. Blümcke · Aktuelle Neurologie · 2006 · Heft 09
Bibliografische Angaben
Zusammenfassung
Purpose: Histopathological investigation of hippocampal specimens obtained from patients with temporal lobe epilepsies shows different degrees of neuronal loss within hippocampal subfields and dentate gyrus. We employed cluster analysis to identify distinct pathological groups. Methods: We obtained 178 surgically resected hippocampal specimens. Neuronal cell counts per mm2 were performed within hippocampal subfields CA1-CA4 and dentate gyrus using immunohistochemistry. These data provided a basis for cluster analysis. All clusters were correlated with clinical data. Results: Cluster analysis revealed five pathol…
