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Functional characterization of novel BRAF fusion gene in pilocytic astrocytomas

H Cin, M Remke, D Sturm, H Witt, S Wolf, A Korshunov, P Lichter, A Kulozik, S Pfister · Klinische Pädiatrie · 2009 · Heft 05

Dokument
1165916
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
H Cin, M Remke, D Sturm, H Witt, S Wolf, A Korshunov, P Lichter, A Kulozik, S Pfister
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222629

Zusammenfassung

Pilocytic astrocytomas (PA) constitute the most common brain tumors in children. Little is known about the molecular mechanisms contributing to the development of PA. Recently, we have identified duplications at chromosome 7q34 harboring the BRAF locus in 53% (28/53) of PA. Jones and colleagues could show that this tandem duplication results in a novel fusion gene between KIAA1549 and BRAF (Cancer Res 2008). Notably, these fusion products include the BRAF kinase domain but lack the autoinhibitory N-terminal domain, which could result in constitutive activation of BRAF. To identify novel breakpoints and fusion pr…

Schlagworte

Fusion Novel Could Identify Product Functional Pilocytic Astrocytomas Molecular Products Kinase Domain Klinische Pädiatrie