CareLit Fachartikel
Specific sialylation patterns of neuroblastoma – mechanism of immune evasion?
I Gondesen, F Gieseke, P Mang, R Handgretinger, I Müller · Klinische Pädiatrie · 2009 · Heft 05
Dokument
1165917
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Aberrant glycosylation and high expression levels of lectins are frequently observed properties of human tumors, and are known to be involved in immune evasion mechanisms. Especially for neuroblastoma, we analysed cell surface glycosylation of neuroblastoma cell lines for a better understanding of lectin dependent immune evasion and its relevance for immunotherapeutic strategies. Altered glycans are potential ligands for a family of sialic-acid-binding immunoglobulin-like lectins (siglecs), which are expressed on immune effector cells. Siglec-7, e.g., plays an important role as an inhibitory receptor on natural…
Schlagworte
Neuroblastoma
Immune
Cells
Siglec-7
Evasion
Ligands
Specific
Patterns
Glycosylation
Expression
Lectins
Lines
Klinische Pädiatrie
