CareLit Fachartikel

Natural Killer cells exhibit direct activity against medical important fungi

S Schmidt, L Tramsen, M Hanisch, S Huenecke, U Koehl, T Lehrnbecher · Klinische Pädiatrie · 2009 · Heft 05

Dokument
1165921
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Schmidt, L Tramsen, M Hanisch, S Huenecke, U Koehl, T Lehrnbecher
Ausgabe
Heft 05 / 2009
Seiten
–
Erschienen: 2009-05-11 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0029-1222679

Zusammenfassung

Whereas animal models revealed a crucial role for the recruitment of Natural Killer (NK) cells to the infected tissue in the host defense against fungi, the antifungal activity of NK cells is little investigated. We incubated fresh purified unstimulated and IL-2 stimulated human NK cells with Aspergillus fumigatus or Candida albicans. Increasing E:T (NK cell:fungus) ratio resulted in increasing damage of both fungi in a time dependend manner. However, compared to unstimulated NK cells, stimulated NK cells demonstrated higher killing potency. Analysis of the NK specific cytokines via ELISA showed a correlation of…

Schlagworte

Aspergillus fumigatus Candida albicans Aspergillus Antibodies Cytokines Candida Klinische Pädiatrie