CareLit Fachartikel
The heavy chain immunoglobulin repertoire of human neonatal B cells – human neonatal B cells
P Richl, H Morbach, U Stern, G Girschick, P Lipsky, HJ Girschick · Zeitschrift für Geburtshilfe und Neonatologie · 2009 · Heft 04
Dokument
1165938
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
The random usage of V, D and J genes and their imprecise recombination, somatic hypermutations, together with the random recombination of heavy and light chains leads to immense antibody diversity. The neonatal immunoglobulin repertoire is significantly different to the adult one, as shown in several studies. But most of these studies focus on the age-related changes in the CDR3 of the heavy chain. The goal of our study was to assess the usage of VH genes in the neonate. By using a single-cell PCR approach with genomic DNA as template we were able to detect both the productively and non-productively rearranged V…
Schlagworte
development
heavy chain immunoglobulin
human neonatal B cells
immune repertoire
repertoire
Antibody Diversity
Arthritis
Blood
Zeitschrift für Geburtshilfe und Neonatologie
