Ga-68 DOTATOC-PET/CT in neuroendocrine tumors (NETs): Is an additional bone scan necessary for the detection of skeletal metastases?
S Strobel, W Bohle, TM Welzel, WG Zoller, T Eichele, H Bihl · Zeitschrift für Gastroenterologie · 2009 · Heft 06
Bibliografische Angaben
Zusammenfassung
Aim: In-111 DTPA-octrotide (In-111 DTPAOC) has proven its usefulness in the detection of somatostatin receptor (STTR) expressing NETs and their metastases. One of the major problems of this imaging modality is its limited sensitivity in detecting small lesions, particularly of the skeletal system, even if it is carried out in SPECT-technique. Ga-68 DOTA-D-Phe(1)-Tyr(3)-octreotide (Ga-68 DOTOATOC) is a new PET radiotracer with a higher affinity to STTR2 compared to In-111 DTPAOC. In this study we evaluated the clinical performance of Ga-68 DOTATOC-PET/CT and conventional bone scintigraphy in detecting skeletal me…