In vivo assessment of neuronal dysfunction in rats transgenic for Huntington's disease using small animal FDG-PET and MRI – a 16 months follow-up study
V Lippross, S Hermann, N Nagelmann, J Heselhaus, S Bohlen, H Kugel, M Deppe, J Sommer, C Bremer, H Nguyen, O Riess, S von Hörsten, M Schäfers, R Reilmann · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Huntington's Disease (HD) is a dominant neurodegenerative disorder. Human FDG-PET and MRI imaging show functional changes and signs of atrophy in the striatum, even in pre-manifest HD. Transgenic animal models of HD provide invaluable insights into disease mechanisms and may facilitate evaluation of new therapeutic targets. Several established rodent models, e.g., the R6/2 and YAC-128 mice, carry CAG-repeat expansions far longer than usually observed in humans. In contrast, the tgHD rat carries 51 CAG repeats, which is within ranges observed in human genotypes. It was previously reported that small a…
