The 1000Plus study protocol – a prospective observational study on the mismatch concept in a 3.0 T MRI
B Hotter, S Pittl, M Ebinger, G Oepen, K Jegzentis, K Kudo, M Rozanski, WU Schmidt, P Brunecker, C Xu, M Endres, GJ Jungehülsing, A Villringer, JB Fiebach · Aktuelle Neurologie · 2009 · Heft 10
Bibliografische Angaben
Zusammenfassung
Background: Stroke MRI and the mismatch of DWI lesion and perfusion imaging (PI) deficit volumes may help to replace CT guided selection for thrombolysis based on a rigid time frame and hemorrhage exclusion. Two studies, DEFUSE and EPITHET, investigated the mismatch concept with relatively low recruiting rates. Therefore, confirmation of the positive results in a larger cohort is desirable. Provided with a purely research dedicated 3T MR scanner installed on the neurologic ward we are able to screen all patients with a suspected cerebrovascular event. We hypothesize that the prognostic value of the mismatch conc…
