Long-term follow-up of two patients with multiple sclerosis treated with allogeneic stem cell transplantation for chronic myeloid leukaemia

Background: We report on the longterm follow-up of two patients with relapsing-remitting multiple sclerosis and concomitant chronic myeloid leukemia (CML) treated with allogeneic hematopoietic stem cell transplantation (HSCT). Case presentation: The first patient was 35 years old with a 4 year history of relapsing remitting MS (RRMS) when diagnosed with philadelphia chromosome positive CML and treated with allogeneic HSCT in 1997. Her symptoms so far included optic neuritits with persistent reduced visual acuity and recurrent sensory abnormalities. Visual acuity was found normal 2 years after the transplantation…