Ablation of Gly96/Immediate Early Gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-kappaB
A Arlt, C Sina, O Gavrilova, E Midtling, ML Kruse, M Großmann, R Kumar, UR Fölsch, S Schreiber, P Rosenstiel, H Schäfer · Zeitschrift für Gastroenterologie · 2009 · Heft 09
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Zusammenfassung
Aims: Inflammatory bowel diseases (IBD) result from environmental and genetic factors and are characterized by an imbalanced immune response in the gut and deregulated activation of the transciption factor NF-kappaB. Goal: Addressing the role of the stress associated early response gene IEX-1/IER3 (murine homologue: gly96) in the regulation of NF-kappaB in IBD, we used the DSS colitis model in mice in which the gly96/iex-1 gene had been deleted. Methods: C57BL/6 mice of gly96/iex-1 -/- or gly96/iex-1 +/+-genotype were treated continously with 4% DSS (6 days) and repeatedly with 2% DSS (28 days) for inducing an a…
