Common genetic variation in the p53/mdm2 network and cholangiocarcinoma susceptibility
V Zimmer, F Grünhage, G Assmann, K Römer, M Pfreundschuh, T Sauerbruch, F Lammert, A Höblinger · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background & aim: Aberrant cell cycle regulation and apoptosis has been implicated in biliary carcinogenesis (Blechacz B, Hepatology 2008). The tumor suppressor gene p53 and its key negative regulator mdm2 cooperate in regulating these processes, and germline p53 alteration has been shown to promote cholangiocarcinoma (CCA) formation in animal models (Farazi P, Cancer Res 2006). Common functional sequence variants of p53 (SNP72 G/C) and mdm2 (SNP309 T/G) have been demonstrated to modulate cellular apoptotic capacity and cell cycling properties (Whibley C, Nat Rev Cancer, 2009). Here, we aimed at assessing the pu…
