CareLit Fachartikel
Galiellalactone inhibits pro-fibrogenic TGF-β effects in hepatic stellate cells
J Li, G Erkel, S Wölfel, C Meyer, J Dzieran, HL Weng, S Dooley · Zeitschrift für Gastroenterologie · 2009 · Heft 09
Dokument
1166392
CareLit-ID
Jahr
2009
Publikation
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Metadaten
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Zusammenfassung
Background: Galiellalactone is a natural fungal metabolite isolated from the ascomycete Galiella rufa and was primary screened out as an inhibitor for IL-6/Stat3 signaling. It has been reported that galiellalactone induces apoptosis of phospho-Stat3 positive prostatic carcinoma cells and reduces mouse prostatic tumor xenograft growth. Recently we found that galiellalactone also inhibits the downstream signaling of TGF-β, a key regulator of liver fibrogenesis. Aim: The aim of this study is to investigate whether galiellalactone is a potential drug against fibrogenesis in the liver. Methods: Primary cultured hepat…
Schlagworte
Apoptosis
Caspase 3
Connective Tissue Growth Factor
Connective Tissue
Actin
Tumor
Zeitschrift für Gastroenterologie
