CareLit Fachartikel

Differential effects of multikinase kinase inhibitors sorafenib and U0126 on phosphorylation patterns of hepatocellular carcinomas cells

C Quack, E Rieser, M Braun, S Maßen, AF Koch, M Müller, CS Falk · Zeitschrift für Gastroenterologie · 2009 · Heft 09

Dokument
1166401
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Quack, E Rieser, M Braun, S Maßen, AF Koch, M Müller, CS Falk
Ausgabe
Heft 09 / 2009
Seiten
–
Erschienen: 2009-09-28 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1241649

Zusammenfassung

Introduction: Hepatocellular carcinoma (HCC) represents one of the most prevalent cancer entities world wide. A variety of molecular mechanisms and signalling pathways are involved in hepatocarcinogenesis. Among these, the MAP kinase (RAS/RAF/MEK/ERK) signalling pathway plays an essential role in the regulation of hepatocyte proliferation and metabolic function. Dysregulation of this signalling pathway following mutation or constitutive activation is critical in HCC pathogenesis and highlights it as an attractive therapeutic target. Sorafenib, an oral drug developed as B-RAF inhibitor, has been shown to be a pro…

Schlagworte

Inhibitors Kinase Sorafenib Phosphorylation Effects U0126 These Pathway Other Kinases Differential Multikinase Zeitschrift für Gastroenterologie