CareLit Fachartikel

The development of selective Inhibitors of H. pylori gamma-glutamyltranspeptidase

C Bolz, B Kalali, J Probst, F Anderl, DH Busch, M Gerhard · Zeitschrift für Gastroenterologie · 2009 · Heft 10

Dokument
1166438
CareLit-ID
Jahr
2009
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Bolz, B Kalali, J Probst, F Anderl, DH Busch, M Gerhard
Ausgabe
Heft 10 / 2009
Seiten
–
Erschienen: 2009-10-15 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1242259

Zusammenfassung

All Helicobacter pylori infected patients develop chronic gastritis, which may proceed to gastric cancer. Despite a strong local and humoral immune response, the bacterium is not eliminated. In earlier studies, we have identified the gamma-glutamyltranspeptidase (gGT), which is secreted by H. pylori as a central inhibitor of the human immune response in the stomach by inhibiting lymphocyte proliferation. Such effect towards lymphocytes is not described for gamma-glutamyltranspeptidases from any other species. We have therefore expressed and purified gGTs from different species in order to compare the substrate s…

Schlagworte

Pylori Species Inhibitors Effect Selective Gamma-Glutamyltranspeptidase Helicobacter Develop Which Immune Response Identified Zeitschrift für Gastroenterologie