Chorionic Villous Sampling: Analysis of the first 350 singleton pregnancies by a single operator

Objective: To assess the factors that might influence the success rate, safety and reliability of chorionic villus sampling. Design: Analysis of the outcome of 350 cases of CVS (215 transabdominal and 135 transvaginal). Setting: The outpatients prenatal diagnosis and therapy laboratory of a university tertiary care centre. Subjects: 350 pregnant women that underwent CVS for prenatal genetic diagnosis between 9 and 32 gestational week. Results: Fetal genotype was the most common indication for CVS 45% (158/ 350). The overall Sampling success rate was 98% (343/350).The majority of cases 92% (322/350) required one…