hCG reduces leptin release in the dual in vitro placenta perfusion model

Background: High maternal hCG levels were found in preeclampsia and in conditions of fetal growth retardation. Since leptin may be involved in the pathophysiology of preeclampsia and fetal growth we are interested in the effect of hCG on placental leptin release and general placental function. Aim: Investigation of the effect of hCG on placental function and leptin release. Material & Methods: 21 placentas at term; dual in vitro placenta perfusion in three groups: A: control; B: hCG conc. 5000 mIU/mL; C: hCG conc. 10.000 mIU/mL. Hormone release rates were measured after 3h and 6h of perfusion. Determination of h…