The Interleukin 13 Receptor System: A Novel Pathogenetic Mechanism in Pulmonary Arterial Hypertension
M Hecker, G Kwapiszewska, A Zakrzewicz, L Marsh, U Seay, D Sedding, N Weissmann, W Klepetko, W Seeger, O Eickelberg · Pneumologie · 2007 · Heft 02
Bibliografische Angaben
Zusammenfassung
Interleukin (IL)-13 controls airway hyperresponsiveness and airway smooth muscle cell (SMC) hypertrophy, but its effect on pulmonary artery SMC has not been investigated thus far. Here, we examined the expression and activity of the IL-13 system in pulmonary arterial hypertension (PAH), including the receptor isotypes IL-4R, IL-13RA1, and IL-13RA2. Using quantitative RT-PCR, we detected increased expression of IL-13RA2 in lungs of PAH patients compared with controls (transplant donors). In contrast, no differences were observed in IL-13, IL-4R, or IL-13RA1 expression. Similar results were obtained in lungs of mi…
