CareLit Fachartikel

Snail and Slug are Key Mediators of TGF-beta-induced Epithelial-to-Mesenchymal Transition in Lung Fibrosis

A Jayachandran, M Koenigshoff, M Hecker, H Yu, E Rupniewska, K Kitowska, W Seeger, O Eickelberg · Pneumologie · 2007 · Heft 02

Dokument
1166888
CareLit-ID
Jahr
2007
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Jayachandran, M Koenigshoff, M Hecker, H Yu, E Rupniewska, K Kitowska, W Seeger, O Eickelberg
Ausgabe
Heft 02 / 2007
Seiten
–
Erschienen: 2007-02-15 00:00:00
ISSN
0934-8387
DOI
10.1055/s-2007-967249

Zusammenfassung

Rationale: Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an increase of interstitial fibroblasts and excessive extracellular matrix deposition, in part mediated through enhanced TGF-β signaling. Epithelial-to-mesenchymal transition (EMT), the reversible phenotypic switching of epithelial to fibroblast-like cells, has recently been proposed as a causative factor in tissue fibrosis, but its precise role in lung fibrosis remains to be resolved. Methods: We analyzed whether EMT occurs in human A549 and mouse primary alveolar epithelial cells (AEC), whether TGF-β is a key inducer of EM…

Schlagworte

Bleomycin After Chromatin Immunoprecipitation Chromatin Actin Pneumologie