Adenoviral gene delivery of interleukin-10 inhibits kupffer cells avtivation in vitro

Aims: Kupffer cells (KC) are the resident macrophages of the liver representing 80% of the total fixed macrophage population. They are involved in several disease states such as endotoxin shock, alcoholic liver diseases, and other toxicant- induced liver injury. They release physiologically active substances, such as eicosanoids and inflammatory cytokines as IL–6 or TNFα, produce free radical species, and are activated like other macrophages by endotoxin (LPS). The multifunctional cytokine Interleukin–10 (IL–10) is known for its general ability to inhibit activation and effector function of macrophages. AIM: Her…