HGF mediated downregulation of the novel gene MIA2 promotes progression of hepatocellular carcinoma
C Hellerbrand, J Schlegel, T Amann, T Spruss, U Dierssen, A Hartmann, F Bataille, C Trautwein, A Bosserhoff · Zeitschrift für Gastroenterologie · 2007 · Heft 01
Bibliografische Angaben
Zusammenfassung
Recently, we identified a novel gene of the MIA gene family, Melanoma Inhibitory Activity 2 (MIA2) and found that MIA2 is selectively expressed in hepatocytes. In contrast, only low MIA2 expression levels were detected in most hepatocellular carcinomas (HCC) and HCC cell lines. Here, we aimed to determine the regulation and functional role of MIA2 in hepatocancerogensis and liver regeneration. In both conditions, hepatocyte growth factor (HGF) is known to be highly expressed and to play a central role, however, the underlying mechanism are still incompletely understood. Methods and Results: By stable transfectio…
