ERbeta is a negative regulator of the PPARgamma in vivo

Aims: The estrogen receptors (ERs) and the peroxisome proliferator-activated receptor gamma (PPARgamma) are members of the nuclear hormone receptor family (NHR) which act as eukaryotic ligand-dependent transcription factors. The molecular mechanisms underlying PPARgamma function are similar to those of ER-signaling. Importantly, PPARgamma is sharing an identical pool of nuclear cofactors with ERbeta which provides a platform for mutual interactions between these two NHRs. The PPARgamma is a major regulator of glucose and lipid metabolism. Furthermore PPARgamma was shown to be also a key player in arteriosclerosi…