CareLit Fachartikel
Genes on rat chromosome 3 are involved in the development of obesity and sex-specific dyslipidemia: Lesson from congenic DA.WOKW rats
R Baguhl, P Lutze, B Wilke, I Klöting · Diabetologie und Stoffwechsel · 2007 · Heft 08
Dokument
1167244
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Jahr
2007
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Zusammenfassung
Aim: WOKW rats develop a number of facets of the metabolic syndrome which is polygenetically inherited as shown by mapping of quantitative trait loci (QTLs) for single facets on different chromosomes in a cross of WOKW and disease-resistant DA rats. Beside others, a QTL for total cholesterol was mapped on chromosome 3. To confirm this QTL, chromosome 3 congenic DA.WOKW rats (DA.3W) were generated, genetically and phenotypically characterised. Methods: DA.3W rats were generated as speed-congenics by a cross of WOKW and DA rats using marker-aided selection. The resulting cross hybrids were repeatedly backcrossed w…
Schlagworte
Cholesterol
Alleles
Obesity
Blood Glucose
Chromosomes
Blood
After
Diabetologie und Stoffwechsel
