CareLit Fachartikel

Regulation of VEGF, HIF-2α, and TIMP-1 in human breast cancer cells by angiotensin II and its receptor antagonist candesartan

D Herr, M Rodewald, G Hack, R Konrad, R Kreienberg, C Wulff · Geburtshilfe und Frauenheilkunde · 2007 · Heft 06

Dokument
1167347
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
D Herr, M Rodewald, G Hack, R Konrad, R Kreienberg, C Wulff
Ausgabe
Heft 06 / 2007
Seiten
–
Erschienen: 2007-06-11 00:00:00
ISSN
0016-5751
DOI
10.1055/s-2007-983499

Zusammenfassung

1. Background: The present study examined the effect of angiotensin II on the regulation of different angiogenesis associated genes in human breast cancer cells and attempted to determine whether administration of At1R blocker candesartan could suppress the angiotensin II dependent gene regulation. 2. Methods: Angiotensin II dependent expression of vascular endothelial growth factor (VEGF), tissue inhibitor of matrix metalloproteinases 1 (TIMP-1), and hypoxia inducible transcription factor 2α (HIF-2α) as well as administration of angiotensin II and At1R blocker candesartan was analyzed in MDA-MB 468 human breast…

Schlagworte

Angiotensin II Breast Angiotensin Tumor Lead Geburtshilfe und Frauenheilkunde