Cortical spreading depression and peri-infarct depolarisation in human ischaemic stroke: a multicentre study (Co-operative Study on Brain Injury Depolarisations, COSBID)

Objective: Cortical spreading depression (CSD) and peri-infarct depolarisation (PID) have been shown in various experimental models of stroke to cause infarct expansion and secondary neuronal damage. For many years it has been speculated that CSD/PID occur in patients with ischaemic stroke. Recently, CSD and PID have been documented in patients with subarachnoid hemorrhage and traumatic brain injury. In the present study, we report for the first time on CSD/PID in human ischaemic stroke. Methods: Patients were recruited by centres of the Co-operative Study on Brain Injury Depolarisations (COSBID). The study was…