Re-challenge with temozolomide at recurrence in high-grade gliomas
P Hau, CP Beier, D Beier, O Grauer, B Hirschmann, T Jauch, C Wismeth, M Proescholdt, U Bogdahn · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Temozolomide (TMZ) is standard therapy for patients (pts) with high-grade gliomas (HGG). Recent data suggest potentially enhanced efficacy of alternative schedules of TMZ administration based on optimizing depletion of MGMT. However, no prospective data have been published on the efficacy of TMZ regimens after failure of first-line TMZ (FL-TMZ). We therefore assessed the outcome of rechallenge with TMZ in pts with HGG. Methods: A retrospective review of pt with recurrent HGG who were rechallenged with TMZ between Jan 2000 and Oct 2006 was conducted. Standard criteria for rechallenge were as follows:…
