CareLit Fachartikel
A novel hexameric CD95 ligand as a potent agonist of apoptosis in human glioma cells in vitro and in vivo
G Eisele, S Aulwurm, U Naumann, P Roth, M Dupuis, M Weller · Aktuelle Neurologie · 2007 · Heft 09
Dokument
1167513
CareLit-ID
Jahr
2007
Publikation
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Zusammenfassung
Glioblastoma is the most aggressive primary human brain tumor. One feature of the malignant phenotype of gliomas is resistance to CD95-induced apoptosis. CD95/Fas/APO-1 is a member of the tumor necrosis factor (TNF) receptor family. Activation of CD95 leads to caspase-dependent apoptotic cell death in sensitive cells. The soluble form of monomeric CD95 ligand fails to initiate this death cascade but it becomes active upon cross linking. Here we report the pro-apoptotic potency of a novel hexameric CD95 ligand (FasL) called MegaFas ligand (MFL) in glioma cell lines and primary glioma cell cultures in vitro and in…
Schlagworte
Apoptosis
Tumor
Adiponectin
Annexin V
Caspase 3
Aktuelle Neurologie
