Genetic variation in the lymphotoxin alpha pathway and the risk of ischaemic stroke
M Dichgans, A Gschwendtner, S Bevan, P Lichtner, S Ripke, B Müller-Myhsok, E Wichmann, H Markus, T Meitinger, T Freilinger · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background and purpose: Recent evidence suggests a role of the lymphotoxin alpha pathway in myocardial infarction (MI). Genetic variation in the LTA, LGALS2 and PSMA6 genes is associated with MI in Japanese (Ozaki et al., Nature Genetics 2002 and 2006, Nature 2004). Given the close relationship between MI and ischaemic stroke (IS) and the involvement of inflammatory cytokines in atherosclerosis, the LTA, LGALS2 and PSMA6 genes represent candidate genes also for IS. We therefore set out to perform a comprehensive analysis of all three genes using SNP and haplotype association tests in a large European IS sample.…
