Physical activity fails to rescue impaired hippocampal neurogenesis in R6/2 mice model of Huntington's disease

Huntington's disease (HD) is a dominantly inherited disorder characterized by hyperkinesia, cognitive deficits and psychiatric symptoms. HD is caused by an expanded CAG-triplet nucleotide repeat stretch on HD gene that encodes for an extended poly-glutamine tract in the huntingtin protein, resulting in intracellular aggregate formation and neurodegeneration. Adult stem cells are considered as potential therapeutic strategy for HD. The generation of new neurons from adult stem cells is privileged in two regions of the adult brain, the subventricular zone of the lateral ventricle and the hippocampal dentate gyrus.…