CareLit Fachartikel
Oxidative metabolism in mitochondrial disease evaluated with near-infrared spectroscopy of skeletal muscle
TJ Müller, M Deschauer, S Zierz · Aktuelle Neurologie · 2007 · Heft 09
Dokument
1167544
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Jahr
2007
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Zusammenfassung
Objective: To evaluate the oxidative metabolism in skeletal muscle of patients with mitochondrial disease with near-infrared spectroscopy (NIRS). Design: In a series of 16 patients with genetically defined mitochondrial disease the production of deoxyhemoglobin (dHb) in the knee extensors during graded bicycle exercise (from 20 W to individual maximum) and in the ankle dorsiflexors upon electrical stimulation (isometric contractions, stimulus rates from 0.2 to 5/s) were measured by NIRS. The dHb production of skeletal muscle was correlated with lactate, cytochrome c oxidase activity, and with the proportion of m…
Schlagworte
Cytochrome C
Cytochrome
Workload
Citrate
After
Aktuelle Neurologie
