Hippocampal volume is an independent predictor of global cognitive performance in pure cerebral small vessel disease
M Sullivan, E Ngo, A Viswanathan, E Jouvent, A Gschwendtner, P Saemann, M Duering, C Pachai, M Bousser, H Chabriat, M Dichgans · Aktuelle Neurologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Hippocampal atrophy is a hallmark of Alzheimer's disease (AD), but its importance in cerebral small vessel disease (SVD) is unclear. Attempts to study this in sporadic SVD are hampered by the advanced age of many patients and the presence of co-morbid neurodegenerative pathology. To clarify the role of hippocampal changes in SVD we investigated patients with CADASIL, a model of pure SVD and associated cognitive impairment. Methods: 144 patients with CADASIL were recruited from two centres and underwent MRI, clinical and cognitive assessment. Dementia status was recorded according to DSM-IV criteria.…
