Effect of the antispasmodic trospium chloride on anorectal function
A Heer, A Pfeiffer · Zeitschrift für Gastroenterologie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Aims: The parasympathetic innervated smooth muscle M. ani internus is one of the key players of continence and defecation. An increased pressure in the lower anal channel by atropin has recently been reported [Aliment Pharmacol Ther 1998; 12: 747–754]. Trospium chloride, a atropin-like peripheral parasympatholytic antispasmodic, has been shown to exert multiple effects on the GI-tract such as delayed gastric emptying, prolonged oro-coecal time and reduction of phase III of small bowel motility [European Journal of Clinical Pharmacology 1993; 44: 219–223; Gut 1994; 35: 27–33]. The aim of the present study was to…