CareLit Fachartikel

Toll-like receptor dependent activation of antigen presenting cells affects adaptive immunity to Helicobacter pylori

R Rad, L Brenner, A Krug, P Voland, S Bauer, RM Schmid, C Prinz · Zeitschrift für Gastroenterologie · 2007 · Heft 09

Dokument
1167587
CareLit-ID
Jahr
2007
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
R Rad, L Brenner, A Krug, P Voland, S Bauer, RM Schmid, C Prinz
Ausgabe
Heft 09 / 2007
Seiten
–
Erschienen: 2007-09-05 00:00:00
ISSN
0044-2771
DOI
10.1055/s-2007-988329

Zusammenfassung

Aims: Helicobacter pylori leads to a chronic inflammation of the gastric mucosa, but mechanisms of immune response are poorly understood. Recognition of infection leads to induction of adaptive immunity through activation of antigen-presenting cells (APCs). Among APCs, dendritic cells (DCs) have the unique capacity to deliver antigens from the periphery to T cells in secondary lymphoid organs. Methods: We analyzed molecular mechanisms of the H. pylori-induced APC-activation in vitro and investigated the influence of Myd88-signalling on the phenotype of adaptive immunity to H. pylori in a murine infection model.…

Schlagworte

Adaptive Immunity Antigen-Presenting Cells Activation Analysis Dendritic Cells Cytokines Antigens Bacteria Zeitschrift für Gastroenterologie