Highly improved test performance for prenatal aneuploidy screening by the novel ‘Advanced Firsttimester Screening’

Objective: The common background risk for trisomy 21 does not regard to the individual pregnancy and it was postulated to completely exclude the age depending component from firsttrimester screening. It was the aim of this study to verify a new algorithm, which is called 'Advanced Firsttrimester Screening' (AFS), disregarding the age. Materials and methods: In a multicenter study the measurement values of a firsttrimester screening were retrieved from 10,116 pregnancies. Risk assessment was performed by Nicolaides' method (FTS) and in addition an AFS score has been calculated. Statistical significance was tested…