Adiponectin effects on human breast cancer cells are dependent on 17-ß estradiol
G Pfeiler, C Büchler, M Neumeier, A Schäffler, G Schmitz, O Ortmann, O Treeck · Senologie - Zeitschrift für Mammadiagnostik und -therapie · 2007 · Heft 09
Bibliografische Angaben
Zusammenfassung
Adiponectin, an adipocyte derived serum protein, is known to positively affect glucose and lipid metabolism and these effects are mediated by its receptors, AdipoR1 and 2. Serum adiponectin levels are inversely associated with breast cancer risk, but the molecular mechanisms underlying this association are not fully elucidated. Thus, the purpose of this study was to investigate the influence of adiponectin on breast cancer cells in vitro. We were able to demonstrate expression of AdipoR1 and AdipoR2 in MCF-7, MDA-MB-231 and SK-BR-3 breast cancer cells on the mRNA level. Furthermore, AdipoR1 protein could be dete…
